Live Prescriber SignalReal-Time

The missing layer in 
real-world evidence

RWEengine™ captures physician intent and clinical confidence before a prescription is written — not months after it appears in claims.

Claims data lags 3–6 months. By the time it appears, the decision is already over. RWEengine™ operates upstream — at the moment decisions are formed.

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Live

DUPIXENT® Intelligence

Atopic Dermatitis · Sanofi / Regeneron

Q4 2024
TVI
+3.2
87
RVI
+1.8
92
Prescribing Likelihood
-2.1
78%
Verified Reviews
+12
n=847

Adoption Stack

n=847
Efficacy
89%
Tolerability
81%
PA Burden
48%34% ↑23%
Adherence
74%

Trending Signals

Efficacy ConfidencePeer AdvocacyPA FrictionStep Therapy30-day Intent
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TVI™Therapy Value Index — composite real-time scoreRVI™Relative Value Index — competitive positioning23%30-day prescribing intent signalClinical Confidence Index— leading indicator of divergence12%PA friction trending down in NortheastPrescriber Advocacy Score— peer propagation velocityn=847verified physician reviews active4.2ptsTVI™ gain this weekBarrier Intelligence— upstream of utilization dataRWEengine™by Alpha.MD · Patent-PendingTVI™Therapy Value Index — composite real-time scoreRVI™Relative Value Index — competitive positioning23%30-day prescribing intent signalClinical Confidence Index— leading indicator of divergence12%PA friction trending down in NortheastPrescriber Advocacy Score— peer propagation velocityn=847verified physician reviews active4.2ptsTVI™ gain this weekBarrier Intelligence— upstream of utilization dataRWEengine™by Alpha.MD · Patent-Pending
Why It Matters

Claims data tells you
what already happened

RWEengine™ operates upstream of the prescription — capturing physician intent, clinical confidence, and peer dynamics at the moment decisions are formed.

01Timing
Claims
3–6 month lag
RWEengine
Real-time signals
02Signal type
Claims
Rx confirmation only
RWEengine
Intent & decision drivers
03Source
Claims
Administrative records
RWEengine
Declared physician signal
04Causality
Claims
Modeled inference
RWEengine
Causal adoption insights
05Barrier visibility
Claims
Invisible until utilization drops
RWEengine
Months upstream of utilization
06Competitive intelligence
Claims
Lagged share data
RWEengine
Early erosion detection
07Identity
Claims
Attributed, not verified
RWEengine
Verified HCP, anonymous
Claims0/7
RWEengine7/7
Live Intelligence

Six signals that don't
exist in claims data

Every score is derived from real physician input — not modeled, not inferred, not lagging.

TVI

Therapy Value Index

A composite real-time score reflecting perceived clinical and practical value, dynamically updated from physician input across efficacy, safety, adherence, access, and usability.

RVI

Relative Value Index

Head-to-head competitive positioning versus alternatives in the same indication. Detects differentiation or erosion early — before market share shifts appear in any claims dataset.

PLS

Prescribing Likelihood Score

Predictive probability of near-term prescribing in 30–90 days, driven by clinical confidence, peer alignment, access friction, and live engagement signals. This metric does not exist in claims.

CCI

Clinical Confidence Index

Measures prescriber certainty and comfort using a therapy in real-world patients. Serves as an early warning for adoption slowdowns and a leading indicator of guideline divergence.

PAS

Prescriber Advocacy Score

Quantifies peer-to-peer influence and recommendation behavior. Captures propagation potential across physician networks and surfaces momentum beyond individual prescribers.

Live

Barrier Intelligence

Real-time visibility into why adoption stalls — PA burden, payer friction, safety concerns, adherence drop-off, and regional variation — months before they appear in utilization data.

Pre-Launch Intelligence

Early signal access.
Before approval.

RWEengine™ captures prescriber awareness, interest, and intent signals during the pre-approval window — not just after launch. Your intelligence layer is already primed when Day 1 arrives.

Step 1Pre-Approval

Awareness & Interest Signals

Physician awareness, peer discussion, and early clinical interest tracked before the Rx is even possible.

Step 2Launch Window

TVI™, RVI™ & PLS Go Live

All pre-launch signals prime the core metrics — so Day 1 intelligence reflects weeks of accumulated prescriber sentiment.

Step 3Post-Launch

Continuous Adoption Intelligence

The intelligence layer never resets. Barrier signals, competitive shifts, and advocacy scores update in real time as adoption evolves.

“Pre-launch signals feed directly into TVI™, RVI™, and Prescribing Likelihood Scores — creating a continuous intelligence layer from pre-approval through post-launch adoption.”

Plans & Access

Authorized partner access
at every scale

RWEengine™ is available exclusively to vetted partners in pharma, HEOR, and healthcare analytics. Contact us to verify eligibility.

Essentials

per engagement

Single-product intelligence

  • TVI™ & RVI™ for 1 therapy
  • Prescribing Likelihood Score
  • Barrier Intelligence dashboard
  • Quarterly reporting cadence
  • Competitive benchmarking
  • API & data feed access
Most Popular

Intelligence Suite

annual subscription

Full platform · multi-therapy coverage

  • All six live intelligence metrics
  • Multi-therapy & competitive RVI™
  • Real-time dashboard access
  • Specialty & regional segmentation
  • Trend alerts & launch signals
  • Dedicated account management

Enterprise

enterprise licensing

API · HEOR · Data licensing

  • Everything in Intelligence Suite
  • Raw data API & feed access
  • Custom HEOR study design
  • White-label licensing options
  • Unlimited therapeutic areas
  • Executive strategy support
Authorized Partner Portal · Alpha.MD

Access your
intelligence dashboard

View real-time prescriber signals, adoption drivers, and competitive positioning for your product portfolio — updated daily from live physician data.

  • Full 6-metric intelligence dashboard
  • Adoption Stack analytics
  • Barrier Intelligence with trending
  • Specialty & geography segmentation

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